Upper acts as a stimulant, increasing the physical capabilities of the user tremendously at the cost of a reduced lifespan. When overdosed on Upper, users gain severely numbed pain receptors but also run the risk of incurring organ damage and a manic state
Downer is used as a depressant or tranquilliser, slowing the senses and movement. If taken after Upper it can help maintain the body's stability. When overdosed on Downer, it can cause loss of consciousness, risk of organ damage and fatigue.