النتائج (
العربية) 1:
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The purpose of feeding is to restore the caloric homeostasis within the body (the balance between energy supply and energy expenditure). This process controlled by many central and peripheral physiological mechanisms within the human body.[1]The central mechanisms which control food intake involve many CNS regions and including different neurotransmitters and neuropeptides. Of these neurotransmitters, is serotonin (5-hydroxytryptamine).[2]The mechanism, through which, serotonin control food intake is not fully understood. However, there is evidence suggests that serotonin enhance melanocortin 4 receptors (MC4) which is involved in food intake control in the hypothalamus.[3]The relationship between serotonin and feeding, dated back to the 1970s, were scientists found that there is inverse relationship between serotonin level and food intake.[2, 3] From that time, many anti-obesity drugs were developed that modulate serotonin level, but regrettably most of them withdrawn because of their serious adverse effects like fenfluramine and lastly sibutramine.[4]
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